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Purpose: RGB-286638 is a multitargeted inhibitor with targets comprising the family of cyclin-dependent kinases (CDK) and a range of other cancer-relevant tyrosine and serine/threonine kinases. The objectives of this first in human trial of RGB-286638, given i.v. on days 1 to 5 every 28 days, were to determine the maximum tolerated dose (MTD) and to evaluate the pharmacokinetic (PK) and.
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Maja J. A. de Jonge, Martijn P. Lolkema & Diane A. J. van der Biessen. Department of Medical Oncology and Clinical Pharmacology, Netherlands Cancer Institute, Plesmanlaan 12, 11066 CX, Amsterdam, The Netherlands. Neeltje Steeghs & Remy B. Verheijen
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van der Biessen DAJ 1 , Abdul Razak AR 4 , De Vos FYFL 5 , Verheijen RB 2 , Schnell D 6 , Pronk LC 7 , Jansen M 8 , Siu LL 4 Author information. Affiliations. 1. Department of Internal Oncology, Erasmus Medical Centre Cancer Institute, Dr. Molenwaterplein 40, 3015 GD, Rotterdam, The Netherlands..
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abstract = "PURPOSE: To evaluate the safety and tolerability of LiPlaCis, a liposomal formulated platinum compound, in patients with solid tumours and to determine the maximum tolerated dose (MTD) of intravenous (i.v.) LiPlaCis. and to assess plasma and urine pharmacokinetics and plasma biomarkers.PATIENTS AND METHODS: Patients with solid tumours without standard therapeutic options were.
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9551. Background: Phase I trials are essential for progress in cancer treatment but the reasons for patients to participate in these trials remain relatively ill-explored (Van der Biessen et al, 2013). This study aims to understand how psychological factors like coping strategies, locus of control, and hope affect the motivation to participate in these trials.
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We bieden veel keuze in verzorgde dagtochten (bijvoorbeeld met diner), musicals, beurzen of concerten. U reist in een moderne touringcar en uiteraard geldt op onze dagtochten ook de ANVR en SGR garantie! Bekijk hier al onze dagtochten. Van der Biesen Travel, al 110 jaar specialist in busreizen. Busreizen door Europa, geheel verzorgd door Biesel.
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@article{Kitzen2009PhaseID, title={Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours.}, author={Jos J. E. M. Kitzen and Maja J. A. de Jonge and Cor H J Lamers and Falm Eskens and Diane van der Biessen and Leni van Doorn and Judith ter Steeg and Maud Brandely and Christian Puozzo and Jaap.
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The device of new hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylme-thoxyethyl)adenine (PMEA) with specificity for the asialoglycoprotein receptor on parenchymal liver cells is described.
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In addition, Van der Biessen et al. (2018) showed that the motivations of patients leading to a decision to participate can be traced back to the self-determination theory of Ryan and Deci [4, 7]. In this theory, there are three personal needs that influence the motivation behind choice: competence, relatedness, and autonomy . These personal.
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Furthermore, research towards hope at preconsent of phaseâI trial participation showed that hope was the central motivator for participation and positively interacted with HRQoL. Hope formed a pact with coping strategies, such as tenacious and flexible coping, and the feeling of being in control (Van der Biessen et al., 2018).
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The cover image, by Diane A. van der Biessen et al., is based on the Paper Understanding how Coping Strategies and Quality of Life maintain Hope in Patients deliberating Phase-I Trial.
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J J E M Kitzen 1 , M J A de Jonge, C H J Lamers, F A L M Eskens, D van der Biessen, L van Doorn, J Ter Steeg, M Brandely, Ch Puozzo, J Verweij Affiliation 1 Dept of Medical Oncology, Erasmus University Medical Center, EA Rotterdam, The Netherlands. [email protected]
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Diane A. J. van der Biessen, 1 Jourik A. Gietema, 2 Maja J. A. de Jonge, 1 Ingrid M. E. Desar, 3 Martha W. den Hollander, 2 Matthew Dudley, 4 Martin Dunbar, 4 Robert Hetman, 4 Camille Serpenti, 5 Hao Xiong, 4 Rajendar K. Mittapalli, 4 Kirsten M. Timms, 6 Peter Ansell, 4 Christine K. Ratajczak, 4 Stacie Peacock Shepherd. van Herpen C, Gietema.